{"id":114,"date":"2018-11-11T11:32:35","date_gmt":"2018-11-11T19:32:35","guid":{"rendered":"http:\/\/kinaseinhibitorlibrary.com\/?p=114"},"modified":"2022-01-13T16:31:27","modified_gmt":"2022-01-13T09:31:27","slug":"association-mir-21-pancreatic-nsclc-survival","status":"publish","type":"post","link":"http:\/\/kinaseinhibitorlibrary.com\/index.php\/2018\/11\/11\/association-mir-21-pancreatic-nsclc-survival\/","title":{"rendered":"The association of mir-21 with pancreatic and NSCLC survival"},"content":{"rendered":"<p>More importantly, recent studies investigating its association with cancer outcomes have disclosed the prognostic value of mir-21, with its high expression predicting worse survival status in malignancies including breast cancer, lung cancer, pancreatic cancer, colorectal cancer, and so on. However, consensus has not been reached as to the reliability of mir-21 as a prognostic biomarker in cancer because of some opposite results. Considering the weakness of an individual study,<a href=\"http:\/\/www.abmole.com\/products\/echinocystic-acid.html\">Echinocystic-acid<\/a> it\u2019s necessary to perform a meta-analysis to address the inconsistence of literature by systematically summarizing available findings. In the current study, we carried out a meta-analysis to assess the prognostic significance of mir-21 in cancer. Since inconsistent evidence existed about the association of mir-21 with pancreatic and NSCLC survival, we performed cancer-specific subgroup analyses to clarify the correlation of mir-21 with these two malignancies. As for colorectal cancer however,<a href=\"http:\/\/www.abmole.com\/products\/cyanoacetohydrazide.html\">Cyanoacetohydrazide<\/a> the vast majority of available studies demonstrated that mir-21 over-expression could predict poor survival in colorectal cancer, which made it less necessary to re-prove previous finding in our study. In addition, implications for future research and feasibility of application in clinical practice were also explored. In the current meta-analysis which pooled global high-quality studies concerning mir-21 and cancer prognosis, it was demonstrated that over-expression of mir-21, especially in cancerous tissues, was effectively predictive of poor survival in a variety of cancers, in terms of both OS and DFS. For NSCLC and pancreatic cancer, significant association was verified between elevated mir-21 level and worse long-term survival. The studies setting OS as primary endpoint were largely homogeneous, which made it relatively safe to conclude that high level of tissue or circulating mir-21 was predictive of reduced OS. Nevertheless caution should be taken when interpreting the analysis results of the DFS studies, which exhibited prominent heterogeneity. In the subgroup analysis by types of sample, mir-21 level in cancerous tissues rather than blood serum was associated with decreased DFS in multiple cancers.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>More importantly, recent studies investigating its association with cancer outcomes have disclosed the prognostic value of mir-21, with its high expression predicting worse survival status in malignancies including breast cancer, lung cancer, pancreatic cancer, colorectal cancer, and so on. However, consensus has not been reached as to the reliability of mir-21 as a prognostic biomarker &hellip; <a href=\"http:\/\/kinaseinhibitorlibrary.com\/index.php\/2018\/11\/11\/association-mir-21-pancreatic-nsclc-survival\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">The association of mir-21 with pancreatic and NSCLC survival<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"http:\/\/kinaseinhibitorlibrary.com\/index.php\/wp-json\/wp\/v2\/posts\/114"}],"collection":[{"href":"http:\/\/kinaseinhibitorlibrary.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/kinaseinhibitorlibrary.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/kinaseinhibitorlibrary.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/kinaseinhibitorlibrary.com\/index.php\/wp-json\/wp\/v2\/comments?post=114"}],"version-history":[{"count":1,"href":"http:\/\/kinaseinhibitorlibrary.com\/index.php\/wp-json\/wp\/v2\/posts\/114\/revisions"}],"predecessor-version":[{"id":115,"href":"http:\/\/kinaseinhibitorlibrary.com\/index.php\/wp-json\/wp\/v2\/posts\/114\/revisions\/115"}],"wp:attachment":[{"href":"http:\/\/kinaseinhibitorlibrary.com\/index.php\/wp-json\/wp\/v2\/media?parent=114"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/kinaseinhibitorlibrary.com\/index.php\/wp-json\/wp\/v2\/categories?post=114"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/kinaseinhibitorlibrary.com\/index.php\/wp-json\/wp\/v2\/tags?post=114"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}