The various roles of non-coding sequences, such as non-coding RNAs, microRNAs and siRNAs, in genome organization and regulation emphasize the importance in understanding how large megabase-sized regions of the DNA ensure genome stability and chromosome inheritance in meiosis and mitosis. To date no SVCV outbreak has occurred in China. Two world events sparked our great interest in studying SVCV in China. In 1998, SVCV was isolated in goldfish and ornamental carp exported to England from Beijing. In 2002, SVC was recorded in the USA, and that the viral pathogen SVCV was suggested to be linked with imported fish, likely from China, based on gene sequence analysis. Antisense oligonucleotides have been reported to modulate splicing of pre-mRNA transcribed from mutated genes and to restore a normal reading frame in several diseases. Duchenne muscular dystrophy, a degenerative muscle disorder caused mainly by nonsense or frame-shift mutations of the dystrophin gene, is one of the diseases that could be treated by AON-mediated exon skipping. Previously reported studies were conducted in vitro, in animal models, and as patient intervention studies, and they showed restorations of the reading frame in dystrophin mRNA and recoveries of dystrophin protein expression. Among the several AON chemistries that have been introduced thus far, a phosphorodiamidate morpholino oligomer and 2′-O-methyl phosphorothioate oligomer are promising candidates owing to their stabilities and efficacies, and they are now undergoing phase I-II clinical trials in the United Kingdom and the Netherlands, respectively. The AON-mediated exon skipping is already in a late early stage of clinical application; therefore, it is rational to translate pre-clinical animal model knowledge into a patient-based study. The G genes of the isolated SVCV strains in the two incidents were sequenced and named as ”Asian strain”. It is uncertain as to whether SVCV indeed originated from China? For this, we have developed ELISA and real-time quantitative RT-PCR methods in an attempt to isolate and identify SVCV in Beijing area since 2002. From 2002 to 2006, we tested samples from many ornamental fish farms by a cell culture method, and identified only two positive samples from over 7000 fishes located in Miyun of Beijing. Therefore, it is reasonable to suggest a model in which Ctk1, as part of the CTDK-I kinase complex that phosphorylates the RNA polymerase II C-terminal domain and facilitates transcription elongation, also participates in recombination. Ctk1 is also required for BRCA1-induced lethality in yeast through its participation in an mRNA export/decay pathway. Mutants in this pathway which PF-4217903 suppress BRCT-induced lethality in yeast, all exhibit sensitivity to DNA damaging agents. These results suggest that Ctk1 and the CTDK-I kinase complex may contribute indirectly.