However, it is interesting to speculate that it may function as either a positive or negative regulator of innate immune responses to agents associated with asthma exacerbations. Thus, our data shows that the acute OVA and chronic HDM models are appropriate for future studies that aim to decipher the contribution of NLRP12 in asthma exacerbations, which is an area of intense scientific and clinical interest. MK-1775 Idiopathic nephrotic syndrome is a kidney disease defined by a massive proteinuria and hypoalbuminaemia. Primary INS includes two major histological variants: minimal-change nephrotic syndrome and focal segmental glomerulosclerosis, which account for 70% and 20% of INS in children, respectively and 25% each in adults. Both entities are considered as non-inflammatory diseases and are characterized by glomerular epithelial cell injury leading to massive proteinuria. Although MCNS and FSGS with relapse are considered as immunologically-mediated diseases, MCNS has rather a benign course, while the prognosis of FSGS may be more severe, depending of its sensitivity to steroid and immunosuppressive drugs. MCNS is often triggered by immunogenic stimuli such as viral infections, immunizations or allergens. Active disease is associated with alteration of both humoral immunity and cellmediated immunity. The association of MCNS with primary immunological disorders such as Hodgkin’s lymphoma, leukemia and thymoma support the hypothesis of a disorder of the immune system. Production of many cytokines is increased in relapses, suggesting that the disease is associated with perturbations of the transcriptional machinery. The chromosome DNA is tightly folded in complex with histone proteins, forming nucleosomes in a chromatin structure. Initiation of gene transcription is strongly inhibited on such a nucleosomal template. Gene transcription requires restructuring of chromatin with nucleosomal unfolding, leading to a more open access to the DNA. The modifications of chromatin structure and properties include DNA methylation, histone modifications and functional miRNA processing. Compelling evidence supports the interdependence of these epigenetic mechanisms. The INO80 chromatin remodeling complex is a large multisubunit ATP-dependent protein complex that regulates the assembly, disassembly of nucleosomes, facilitating their sliding along DNA. The function of INO80 complex involves transcriptional regulation, DNA repair and DNA replication. The human INO80 complex includes several ATPases, actin-related proteins and non-conserved subunits including the Gli-Kruppel zinc finger transcription factor YinYang 1, the deubiquitylating enzyme Uch37 and nuclear factor related to kB, which has recently been identified as member of this complex. Although the ATPases subunits mediate the ATP-dependent nucleosome remodeling activity, the precise function of the other subunits remains unclear. Evidence from microarray experiments revealed that the INO80 complex contributes to positive or negative regulation of transcription of up to 20% of genes in yeast. In human cells, the INO80 subunit YY1 recruits the complex and controls transcription of a large number of genes. Currently, the role of NFRKB as chromatin remodeling factor remains unknown.