In conclusion, we succeeded in growing corals associated with monoclonal Symbiodinium algae in clades C1 and D, and demonstrated that clade differences can affect the growth rates and fluorescence of juvenile polyps. Clade D algae may contribute to the 
growth of juvenile corals and clade D algae may be more suitable for symbiosis in early growth stages. Furthermore, we suggest that these differences cannot be explained by differences in levels of oxidative stress. To understand the differences between clade C1 and clade D algal associations, further molecular studies are needed. However, our results might not be applied to field corals, because our used symbiotic polyps were cultivated in laboratory conditions. As a model symbiosis system, the corals polyps used in this study were useful to facilitate the molecular analysis. Since it is difficult to maintain juvenile polyps in the laboratory for extended periods, the number of polyps that can be used in experiments was restricted. The development of an incubation system that can maintain a large number of juvenile polyps for experiments, such as gene expression profiling, will be valuable in the future studies. Studies also show patients with genotype 1b were more likely to develop severe disease progression to chronic hepatitis C as compared to other genotypes. Additionally, studies also observed that genotype 1 infected patients had a higher propensity of progressing to hepatocellular carcinoma than other genotypes. However, some studies report that, infection with HCV genotype 3 was associated with faster fibrosis progression and higher degree of portal hypertension. But till now, an increased incidence of HCC in cirrhotic patients infected with genotype 3 has not been documented. The gold standard therapy for chronic hepatitis Cconsists of pegylated interferonand ribavirin, but reports have shown the drugs are not well tolerated. Therefore, it is the need of the hour to identify determinants of response to treatment. Different studies have shown that race, genotype, HCV RNA viral load, age, gender, basal metabolic index, fibrosis are important predictors for information regarding the IFN �Cribavirintreatment response. The impact of IL28B associations in interferon responsiveness amongst Indian population remains understudied. In the current era, new HCV treatment paradigm includes one direct acting antiviral, a protease inhibitor, in combination with Peg-IFN and ribavirin. The addition of DAA to Peg-IFN/RBV nearly doubles the chances of response to treatment but at the cost of increased toxicity. These drugs have shown significant Loganin increase in SVR rates but the problem remains in the developing countries like India, where the DAA is still not introduced and if commenced; initial costs might be high for the people to afford the expensive treatment. Thus, in these clinical settings; IL28B genotyping in Procyanidin-B2 predicting IFN responsiveness would be beneficial for individualizing treatment approaches. The patients who carry favourable alleles might be eligible for shorter and cheaper regimens and inversely with unfavourable alleles would require longer therapy. In the existing study, the host gene polymorphisms at rs12979860 and rs8099917 in the Indian cohort of patients in eastern and north-eastern part of India were investigated. Our study is probably the first attempt to correlate and understand the effects of the polymorphisms in eastern and north-eastern region of India.