The GSSG/2GSH couple has also been shown to play important role in modulating glucose homeostasis: GSH Darglitazone sodium salt infusion in patients with impaired glucose tolerance potentiates b-cell response to glucose, while in diabetic patients it leads to an increase in body glucose disposal. This effect of GSH is also seen in healthy non-diabetic subjects, thus emphasising the importance of GSH in regulating glucose metabolism. Glucose undoubtedly needs to be controlled in diabetic conditions since hyperglycemia is directly responsible for induction of ROS, however, glutathione levels also need to improve significantly since an optimal GSH concentration augments antioxidant defence and decreases susceptibility to ROS-induced damage. We monitored newly diagnosed diabetic patients over a period of eight weeks during which they were treated with oral antidiabetic drugs to control hyperglycemia. We monitored their fasting glucose, HbA1C, and GSH at 0, 4 and 8 weeks. We developed a mathematical model to study how GSH responds to glucose control, in order to identify pathophysiological differences between individuals on therapy. Fasting blood samples were collected at baseline and 4 and 8 weeks later from diabetic patients and non-diabetic subjects. Diabetic patients were advised on diet and physical activity and were put on anti-diabetic drugs to control hyperglycemia as necessary. Patients were also advised not to take any oral antioxidant and multi-vitamin supplements. The following groups of subjects were excluded: pregnant women, individuals with excessive alcohol intake, chronic smokers and those receiving Lambrolizumab antioxidants, those with clinical infection and an inflammatory or malignant disease. Subjects with a recent cardiovascular event and symptomatic heart disease were also excluded. The study protocol was approved by the Institutional Ethical Committee, KEM Hospital and Research Centre, Pune, and written informed consent was obtained from all the individuals after the purpose and nature of the study had been explained. Our results show that patients with newly diagnosed type 2 diabetes mellitus respond to anti-diabetic glucose control medication with improved GSH levels that increase over eight weeks.