This reflects the complex opt-in approach, mediated by the GPs, that is required for current primary care research in the UK today. We achieved a similar inclusion rate to another recently published large scale UK primary care study using the same approach. Our cohort was also predominantly male. Whilst this may represent a selection bias it also reflects the higher prevalence of amongst men. We found the combined prevalence rate of depression and anxiety disorders was 19%; Delafloxacin met the criteria for depressive disorder as measured by the CISR-R. The prevalence of depression was higher when measured by the HADS with 13% of the population scoring as probable cases of depression. The risk predictors we found for depression are similar to those reported in the general population in other studies. Salokangas & Poutanen reported that risk factors for depression in the general population were physical health problems,KIN1400 physical disability, and poor social support. Brown & Harris previously reported the association between social problems and the onset of depression. These associations were recognized by GPs, practice nurses and patients participating in qualitative studies as part of the UPBEAT-UK programme. However a novel finding, reflecting the nature of this population was that reporting still experiencing chest pain was one of the strongest associations with depression independent of associations with other pains and discomfort. The chest pain could be due to the underlying ischaemic heart disease or be a somatic symptom associated with the concurrent depression or perhaps both. Further analyses of our data will elucidate this. The prevalence of depressive disorder was lower than previously reported in one US study of people with CHD living in the community. Egede found a prevalence rate of depression in people with CHD of 15%. Possible explanations for the lower prevalence of depression in our study is response bias – patients with co-morbid depression or anxiety may be less likely to respond to the GP’s letter inviting participation in the study leading to an underestimation of the prevalence rate, but is also likely to represent the sensitivity of instruments used to detect depression.