We next wanted to determine whether bat IRF7 is involved in the production of IFN-a and IFN-b by the MyD88 despite the divergent nature of its MyD88 binding domain. The transactivation activity of bat IRF7 was compared to that of human IRF7 using expression plasmids containing bat or human MyD88 and IRF7 co-transfected with mouse IFN-a4 or IFN-a6 promoter plasmids. In mice, IFN-a4 is the earliest IFN-a induced by viral infection, while IFN-a6 is induced later in the response. A dose of 10 ng or 100 ng of IRF7 was co-transfected with MyD88 for the IFN-a4P and IFN-a6P promoter assay respectively in HEK293T cells. Moreover, it is known that B-cells express very low number of glycoproteins in the resting state, in agreement with our results. Surprisingly, we observed high binding capacity of the protease deficient PicS258A, but not by the heat-denatured Pic protease or SepA, suggesting that the agglutination phenotype is dependent on protease and not on binding activity. We recently showed that Pic and Tsh/Hbp but not SepA were able to cleave O-linked glycoproteins. Another possible explanation for the smaller effect size in humans is the fact that the sample includes human individuals with comorbid disorders, mainly other anxiety disorders and depression. There is evidence that DCS is effective when administered at low doses, a limited number of times, and immediately before or after exposure therapy. Moreover, there were instances when synonyms were initially counted separately because of their spelling, and these duplications had to be resolved manually. Despite these issues, the literature-based discovery methodology increase clearly presents an advantage in the process of discovering new relationships from diverse fields of research. Swanson originally developed the literature-based discovery methodology and has been refining this process for 30 years with the aim of helping investigators discover unknown or unidentified relationships between studies; a problem that has remained poorly understood until now.