Thus, the relatively greater right insular cortex activation by Navy SEALs supports the idea that these individuals deploy more Dryocrassin-ABBA processing resources to the potential aversive or negative affective associations with facial expressions. Moreover, together with the selectively increased activation to angry target faces in Navy SEALs, these individuals may selectively processing facial features that are critical for potentially aversive or negative consequences. It is important to point out, however, that this cross-sectional study cannot be used to differentiate what could be a trait characteristic or whether this is anger-related processing difference is a consequence of training. We have proposed a neuroanatomical processing model as a heuristic guide to understand how one can link optimal performance to how the individual ����feels inside.���� This model focuses on the notion of a body prediction error and consists of four components. First, Morin information from peripheral receptors ascends via two different pathways, the A-beta-fiber discriminative pathway that conveys precise information about the ����what���� and ����where���� of the stimulus impinging on the body, and the C-fiber pathway that conveys spatially and time-integrated affective information. These afferents converge via several way stations to the sensory cortex and the posterior insular cortex to provide a sense of the current body state. Second, centrally generated interoceptive states reach the insular cortex via temporal and parietal cortex to generate body states based on conditioned associations. Third, in the insular cortex there is a dorsal-posterior to inferior-anterior organization from granular to agranular, which provides an increasingly ����contextualized���� representation of the interoceptive state, irrespective of whether it is generated internally or via the periphery. These interoceptive states are made available to the orbitofrontal cortex for context-dependent valuation and to the anterior cingulate cortex for error processing and action valuation.Fourth, bidirectional connections to the basolateral amygdala and the striatum, particularly ventral striatum, provide the circuitry to calculate a body prediction error, and provide a neural signal for salience and learning.