We evaluated this by testing whether medication Phentolamine Mesylate adherence is an intermediary factor leading to poor glycemic control in different sub-segments of the general diabetes population. Although OAMs are considered efficacious in helping diabetes patients to control their glucose, reported levels of ��good adherence�� to drug therapy vary greatly between 38�C84% in several populations studied. When considering physician prescribed regimens, we found relatively low overall adherence rates among the diabetes patients in our study. Inadequate medication adherence was found to have a attributable risk for poor glycemic control. This figure, however, varies considerably from a 54% attributable fraction in patients younger than 30 years of age, in patient 50 years and older. Additionally, 24% of the risk for poor glycemic control is attributable to inadequate medication adherence in the (R)Ginsenoside-Rg3 subgroup of patients with longer duration illness. Our study expands on the current evidence establishing the importance of medication adherence in contributing to poor glycemic control in different sub-groups of a large, general adult diabetes population, achieved through the utilization of an objective adherence measure that incorporates pharmacy dispensing and written prescriptions. We demonstrated that low medication adherence plays a clear mediating role in explaining high rates of poor glucose control, particularly among younger adult diabetes patients, thereby, identifying a key target population for intervention. Many of the past studies evaluating this relationship for poor glucose control have failed to support findings with statistically significant results, mainly due to small sample sizes, as well as to the subjectivity in the adherence measures used. Two large-scale studies have reported an inverse association between medication adherence and poor glycemic control in large populations; however, one study was comprised predominantly of male veterans and, thus, was not representative of a general population, and the other did not establish the relationship in an adjusted model.