Using this Discovery methodology, we found a potential interaction between anandamide and gastric cancer, which was deeply buried in the vast amounts of available data, and which has now been reliably confirmed by experimentation. In our study, anandamide inhibited the proliferation of gastric cancer cells and mediated G2/M cell cycle arrest by altering the expression of the cell cycle regulators. This relationship has been neglected for many years before we identified the unknown relationship. Our study demonstrates that Swanson’s literature-based discovery methodology is a useful way to assist investigators in uncovering novel interactions between studies by efficiently scanning large amounts of literature to strengthen their initial hypotheses. Due to the rapidly increasing numbers of medical publications and electronic databases that are available, it is now necessary to find novel ways to access the relationships between different studies. In this situation, Swanson developed a literaturebased discovery methodology to extract information and predict possible relevance among articles which are not bibliographically connected. This methodology has significance, not only for individual investigators but also for the field of science as a whole. Medical specialists can retrieve articles and find ignored relationships more efficiently, and doing so may lead to greater discoveries relating to public health, all with the help of this discovery procedure.At high doses and/or chronic administration, this substance seems to have a paradoxical antagonistic effect on the NMDA receptor, resulting in reduced effect of extinction of fear in animals. Studies with animal models also indicate the rapid development of tolerance to DCS when it is administered repeatedly and at high doses.