we attributed the intensity of immune response to the single parameter ap. To estimate patient-specific parameters in Ginkgolide-C individual models, we fitted the model by the least-squares method to the pertinent ����training set���� that included all pre-treatment and several initial intreatment PSA values for each patient; the number of training data points could differ among the patients. Next, we used the results to simulate the subsequent course of PSA change and compared the simulation with PSA measurements recorded following measurements in the training set. If prediction accuracy was low, the size of the training set was iteratively increased by a subsequent PSA measurement, subtracting the point from the validation set. To predict PSA dynamics beyond the training set, we simulated each individualized model under the personal vaccination schedule. For each patient, predictions were compared with the clinically observed PSA levels in the validation set. Goodness-of-fit was evaluated pooling together all the validation data points from all the patients. To compare predictions with measurements, we calculated the coefficient of determination, R2, between the predicted and observed PSA values. We probed whether intensifying treatment could improve vaccine Tigecycline efficacy in individual patients. Hence, based on the validated individual models for the nine patients who completed treatment, we simulated the effects of many intensified vaccination protocols for each patient. Intensification included a graded 10 percent increase above the standard vaccine dose or graded oneday reduction of administration interval relative to standard schedule. We singled out individual vaccine administration schedules that should lead to stabilization of PSA levels at the end of treatment, at concentrations not more than 10 percent above the pre-treatment level. For each patient, minimal increase in vaccine dose and minimal reduction in dosing interval that meet the above PSA stabilization criterion are reported in Table 1. We probed whether intensifying treatment could improve vaccine efficacy in individual patients. Hence, based on the validated individual models for the nine patients who completed treatment, we simulated the effects of many intensified vaccination protocols for each patient. Intensification included a graded 10 percent increase above the standard vaccine dose or graded oneday reduction of administration interval relative to standard schedule. We singled out individual vaccine administration schedules that should lead to stabilization of PSA levels at the end of treatment, at concentrations not more than 10 percent above the pre-treatment level. For each patient, minimal increase in vaccine dose and minimal reduction in dosing interval that meet the above PSA stabilization criterion are reported in Table 1. particular attention as targets for pharmaceutical drug discovery. Homomeric a7 nAChRs have high calcium permeability and very rapid desensitization.