In the current study, there were no changes in protein intake during the intervention period. In conclusion, increased fatty fish intake was associated with beneficially considered changes in HDL particles in persons at risk for coronary heart disease. The changes which we saw in large HDL particles could be related to those parameters that are functionally related to reverse cholesterol transport. Thus, our findings could partly explain the known protective effects of fish consumption against the atherosclerosis. A key challenge in biology is to understand how information is coordinated globally within cells to generate and control complex cellular processes, such as cell migration. Succinctly, what is the wiring pattern of regulation that governs a particular cell behavior? Importantly, this raises a second fundamental question that we seek to address herein: is the wiring pattern for a particular process stable and generalizable, or, plastic and contextually dependent? The answer to this second question has important implications for our understanding of both complex biological processes and the design of the experimental strategies to address them. Cell Homatropine Bromide migration is a process of vital importance in numerous physiological and pathological processes including cancer cell metastasis. Cell migration is indeed a highly complex cellular process, arising from a large, self-organizing molecular network to produce behaviors that are dynamic, heterogeneous and adaptable. The dynamism of these behaviors suggests that underlying plasticity in the wiring of the cell migration system might be both more likely and more readily detectable than in relatively constrained cellular phenomena. Thus cell migration provides an appropriate framework within which to assess both the structure and potential plasticity of cellular wiring patterns. Cell migration is the product of interactions and interdependencies operating across molecular, macromolecular, and cellular scales. As noted above, a huge diversity of components comprise the network underlying migration at the 
molecular scale. Such large-scale molecular networks tend to be arranged into hierarchically nested assemblages or modules. These macromolecular modules often represent functional units with distinct roles whose interactions ultimately produce single cell migration behaviors. To understand how cell migration behaviors derive from molecular-, macromolecular- and cellular-scale organization, it is desirable to characterize all scales simultaneously and with sufficient spatiotemporal resolution to delineate functional relationships between features at any scale. Live cell fluorescence imaging provides the spatiotemporal resolution to track individual migrating cells while concurrently monitoring features of their molecular- and macromolecular-scale organization. Unfortunately, such imaging does not permit us to directly observe the complete state of molecular networks underlying cell migration. The canonical means to overcome such limitations on direct observation have been to assemble, piecewise, the functional contributions and relations of individual molecular components through perturbation-based epistasis analyses. Yet, despite facilitating great progress, reductionist perturbation-based approaches alone may be insufficient to provide a Mycophenolic acid systems-level understanding, particularly of dynamic, heterogeneous processes with potentially emergent properties.