While the Cochrane Collaboration is a lead producer of systematic reviews internationally, further evaluation and dissemination of the briefing notes throughout the Cochrane Collaboration network and beyond Cochrane is needed to ensure wider representation of systematic review authors. Through wider dissemination and evaluation efforts we hope to engage more members of the systematic review community in the development of methodological and practical guidance to facilitate sex/gender analysis and foster changes in practice. In recent years, a number of investigations evaluating the constituency of oral fluid have discovered that it may actually reflect an individual’s physiological condition. In fact, multiple groups have identified saliva-based proteomic, transcriptomic, and microbiological markers for Sjo¨gren’s syndrome, inflammatory bowel disease, and even cancers. Although promising, the novelty of using saliva as an effective evaluator of local and systemic health has not found widespread acceptance. Significant skepticism remains regarding how these unique molecular indicators are developed in saliva. Exosomes are small, lipid-bound, spherical structures measuring approximately 30 to 100 nm in diameter. Randomly formed from the invagination of intracellular vesicles, exosomes often contain biologically active host cell lipids, proteins, miRNAs, mRNAs, ncRNAs, and other cellular constituents. Microvesicles containing similar host cell biomolecules and heterogeneous in size may also be formed by the budding-off the cellular membrane. Majority of vesicles isolated from body fluids are referred as exosomes based on their exosomal protein markers. However, the microvesicles do be co-isolated using current available purification method. We, therefore, collectively refer these vesicles as exosome-like microvesicles here. ELMs are known to shed continuously from multiple cell types including: hematopoietic, intestinal epithelial, Schwann, fat, neuronal, fibroblasts, and several tumor cell lines. Many types of cancer cells release ELMs and tumor-derived ELMs carry a wide range of nucleic acids, including miRNA, mRNA, ncRNA and DNA. ELMs containing these nucleic acids have been shown to reflect the genetic status of tumor, and be able to travel to distant site and transfer their cargo to the recipient cells and to induce phenotypic changes. Previous investigations have revealed that tumors are often the primary source of circulating membrane vesicles and increased amount of tumor derived protein, RNA and DNA were found in the blood of cancer patients. In addition to their presence in blood, ELMs are also present in urine, saliva, breast milk, malignant and pleural effusions, synovial fluid, epididymal fluid, and amniotic fluid. Therefore, tissue-specific exosomes with their constituent tissue-specific biomarkers can serve as a biomarker source for the diagnosis, prognosis, and monitoring of disease. Recent evidence has emerged describing a role for ELMs in the processes that govern the induction of discriminatory salivary biomarkers. However, the mechanisms underpinning the etiology and biogenesis of saliva-based biomarkers have not been clearly explained. Understanding how these markers come to exist in oral fluids will both shed light on the body’s capacity for extracellular communication and help credential salivary biomarkers as an acceptable mode for Semaxanib VEGFR/PDGFR inhibitor personalized medical assessment.